Crucial Triad in Pulp-Dentin Complex Regeneration: Dental Stem Cells, Scaffolds, and Signaling Molecules
نویسندگان
چکیده
BACKGROUND: Pulp damage can lead to dentinogenesis impairment, irreversible pulpitis, or pulp necrosis. Despite being the most used endodontic procedure treat damaged pulp, root canal therapy only results in nonvital teeth which are prone fractures and secondary infection. Pulp-dentin regeneration has a potential regenerate structure similar normal pulp-dentin complex, be achieved by combining dental stem cells, scaffold, signaling molecules. This article reviews role of various types scaffolds, molecules, their combinations regenerating complex.CONTENT: Dental cell (DPSC), from human exfoliated deciduous (SHED), follicle (DFSC) were reported complex situ. SHED might more promising than DPSCs DFSCs for since have higher proliferation expression levels Scaffolds characteristics resembling extracellular matrix, thus providing suitable microenvironment transplanted cells. To accelerate process, exogenous molecules often delivered together with different regenerative potential, including induction migration, formation pulp- and/or dentin-like tissue, as well angiogenesis neurogenesis promotion.SUMMARY: Combinations important achieve functional formation. Current trends future directions on endodontics should explored. The right combination could determined based patients’ characteristics. Incomplete overcome applying multiple visits.KEYWORDS: regeneration, endodontics,
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ژورنال
عنوان ژورنال: The Indonesian Biomedical Journal
سال: 2023
ISSN: ['2355-9179', '2085-3297']
DOI: https://doi.org/10.18585/inabj.v15i1.2265